Kareena was born to Sindhi-speaking Babita and Punjabi-speaking Randhir Kapoor  She has an elder sister, Karisma.

She is born in a family of actors for generations, including her great-grandfather, Prithviraj Kapoor; her grandfather, Raj Kapoor; her uncles, Shammi, Shashi, Rishi, and Rajiv; as well as aunt, Neetu Singh, & Jennifer Kendall, the wives of Rishi and Shashi respectively. On her maternal side, her grandfather  Hari Shivdasani, and aunt, Sadhana, have been actors in their own rights.

As a child she studied in Jamnabai Narsee School in Juhu, Bombay, and thereafter was enrolled in Dehra Dun's prestigious Welham Girls' Boarding School. Then she re-located to Harvard for approximately 3 months to take a course in Information Technology and Microcomputers. Upon her return to India, she joined the Government Law College in Churchgate, Bombay, but left it after one year, to enroll in the Kishore Namit Kapoor Acting School.

Her film debut was in the year 2000 with 'Refugee' along with the debut of  Abhishek. She went on to appear in 31 other Hindi movies, and has thus far won four awards for her performances in 'Refugee', 'Chameli', 'Dev', and 'Omkara'