Zayed Khan was born to Bollywood actor Sanjay Khan & Zarine Khan. His sisters are Simone, Farah & Suzanne. Suzanne is married to actor Hrithik Roshan. His cousin Fardeen Khan & his uncle Feroz Khan. His childhood friend is Esha Deol.He married his longtime girlfriend Malaika Parekh. Mallika gave birth to a baby boy name is Zidaan Zayed Abbas Khan.

He studied at Welham Boys School Dehradun and the Kodaikanal International School Kodaikanal. He also studied in London Film School in London UK. His dream of becoming an actor took its roots early on at the age of 8 years when Zayed first went to the sets of Kaala Dhanda Gore Log. From that day, he was clear that he wanted to become an actor.

Zayed Khan debuted in the film Chura Liyaa Hai Tumne. He was nominated in Zee Cine Award Best Male Debut category for this film. His next release was Main Hoon Na where he co-starred with Shahrukh Khan, Sushmita Sen, & Amrita Rao. He played a college student named Lucky. The film was a big hit & he was nominated for Filmfare Best Supporting Actor category, for his role in the film.

Zayed Khan went on an international touring stage show, Rockstars along with Esha Deol, John Abraham, Shahid Kapoor, Mallika Sherawat, & Salman Khan.